Faktor Risiko Mortalitas pada Anak dengan Gagal Ginjal yang Menjalani Hemodialisis: Studi Cross-Sectional di RS Dr. Moewardi Surakarta

Penulis

  • Fidelya Kaamila Hasna Universitas Muhammadiyah Semarang
  • Agus Saptanto Universitas Muhammadiyah Semarang
  • Galih Prakasa Adhyatma Universitas Muhammadiyah Semarang
  • Oky Rahma Prihandani Universitas Muhammadiyah Semarang

DOI:

https://doi.org/10.57218/jkj.Vol5.Iss3.3049

Kata Kunci:

gagal ginjal anak, hemodialisis, mortalitas, hiperkalemia, hipertensi

Abstrak

Gagal ginjal pada anak merupakan kondisi serius yang dapat memerlukan terapi pengganti ginjal seperti hemodialisis dan berkaitan dengan peningkatan mortalitas. Berbagai faktor klinis, termasuk status gizi, anemia, hipertensi, dan gangguan elektrolit, dapat memengaruhi prognosis pasien. Namun, data mengenai faktor yang berhubungan dengan mortalitas pada anak dengan gagal ginjal yang menjalani hemodialisis di Indonesia masih terbatas. Penelitian ini bertujuan menganalisis hubungan usia, jenis kelamin, status gizi berdasarkan tinggi badan menurut umur (TB/U), frekuensi hemodialisis, anemia, hipertensi, dan hiperkalemia dengan mortalitas pada anak dengan gagal ginjal yang menjalani hemodialisis di RS Dr. Moewardi Surakarta. Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional berdasarkan data rekam medis pasien usia 0–18 tahun yang menjalani hemodialisis selama Januari 2022–Desember 2025. Sebanyak 66 pasien memenuhi kriteria penelitian, terdiri atas 15 pasien (22,7%) meninggal dan 51 pasien (77,3%) hidup. Analisis bivariat menunjukkan bahwa status gizi berdasarkan TB/U (p = 0,040), hipertensi (p = 0,012), dan hiperkalemia (p = 0,002) berhubungan signifikan dengan mortalitas. Crude odds ratio menunjukkan bahwa hipertensi memiliki OR 5,273 (95% CI: 1,325–20,984), hiperkalemia OR 10,281 (95% CI: 2,438–43,356), dan status gizi stunted OR 3,625 (95% CI: 1,017–12,927). Hiperkalemia menunjukkan besaran asosiasi terbesar dengan mortalitas. Hasil penelitian menunjukkan pentingnya pemantauan kadar kalium, tekanan darah, dan status pertumbuhan pada anak dengan gagal ginjal yang menjalani hemodialisis. Temuan ini perlu dikonfirmasi melalui penelitian prospektif atau multicenter dengan analisis multivariat.

Referensi

Ahearn, P., Johansen, K. L., McCulloch, C. E., Grimes, B. A., & Ku, E. (2019). Sex Disparities in Risk of Mortality Among Children With ESRD. American Journal of Kidney Diseases, 73(2), 156–162. https://doi.org/10.1053/j.ajkd.2018.07.019

Anjela, P., Hidayati, E. L., & Andriastuti, M. (2024). Faktor yang memengaruhi angka kesintasan pasien penyakit ginjal tahap akhir pada anak dengan dialisis. Fakultas Kedokteran Universitas Indonesia.

Atkinson, M. A., & Furth, S. L. (2011). Anemia in children with chronic kidney disease. Nature Reviews Nephrology, 7(11), 635–641. https://doi.org/10.1038/nrneph.2011.115

Burnier, M., & Damianaki, A. (2023). Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease. Circulation Research, 132(8), 1050–1063. https://doi.org/10.1161/CIRCRESAHA.122.321762

Chesnaye, N. C., Van Stralen, K. J., Bonthuis, M., Harambat, J., Groothoff, J. W., & Jager, K. J. (2018). Survival in children requiring chronic renal replacement therapy. Pediatric Nephrology, 33(4), 585–594. https://doi.org/10.1007/s00467-017-3681-9

Chou, H.-H., Chiou, Y.-Y., Chiou, Y.-H., Tain, Y.-L., Wang, H.-H., Yu, M.-C., Hsu, C.-C., & Lin, C.-Y. (2018). Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis. Journal of Clinical Medicine, 7(11), 414. https://doi.org/10.3390/jcm7110414

Cirillo, L., De Chiara, L., Innocenti, S., Errichiello, C., Romagnani, P., & Becherucci, F. (2023). Chronic kidney disease in children: An update. Clinical Kidney Journal, 16(10), 1600–1611. https://doi.org/10.1093/ckj/sfad097

Flynn, J. T., Kaelber, D. C., Baker-Smith, C. M., Blowey, D., Carroll, A. E., Daniels, S. R., De Ferranti, S. D., Dionne, J. M., Falkner, B., Flinn, S. K., Gidding, S. S., Goodwin, C., Leu, M. G., Powers, M. E., Rea, C., Samuels, J., Simasek, M., Thaker, V. V., Urbina, E. M., & Subcommittee On Screening And Management Of High Blood Pressure In Children. (2017). Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics, 140(3), e20171904. https://doi.org/10.1542/peds.2017-1904

Furth, S. L. (2005). Growth and Nutrition in Children with Chronic Kidney Disease. Advances in Chronic Kidney Disease, 12(4), 366–371. https://doi.org/10.1053/j.ackd.2005.07.007

Gallegos, F. R., Shirode, P., Gilliland, M., Hu, J., Osagie-Ogbeide, A., Sethi, S. K., & Raina, R. (2025). Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations. Journal of Intensive Medicine, 5(4), 323–332. https://doi.org/10.1016/j.jointm.2025.03.005

Hamsa V, & Kamath N. (2022). Optimizing the hemodialysis prescription and assessment of dialysis adequacy in children. Asian Journal of Pediatric Nephrology, 5(2), 56–63.

Kellum, J. A., Romagnani, P., Ashuntantang, G., Ronco, C., Zarbock, A., & Anders, H.-J. (2021). Acute kidney injury. Nature Reviews Disease Primers, 7(1), 52. https://doi.org/10.1038/s41572-021-00284-z

Kurzinski, K. L., Xu, Y., Ng, D. K., Furth, S. L., Schwartz, G. J., Warady, B. A., & for the CKiD Study Investigators. (2023). Hyperkalemia in pediatric chronic kidney disease. Pediatric Nephrology, 38(9), 3083–3090. https://doi.org/10.1007/s00467-023-05912-2

Larkins, N. G., & Craig, J. C. (2024). Hypertension and Cardiovascular Risk Among Children with Chronic Kidney Disease. Current Hypertension Reports, 26(10), 389–398. https://doi.org/10.1007/s11906-024-01308-1

Laskin, B. L., Huang, G., King, E., Geary, D. F., Licht, C., Metlay, J. P., Furth, S. L., Kimball, T., & Mitsnefes, M. (2017). Short, frequent, 5-days-per-week, in-center hemodialysis versus 3-days-per week treatment: A randomized crossover pilot trial through the Midwest Pediatric Nephrology Consortium. Pediatric Nephrology, 32(8), 1423–1432. https://doi.org/10.1007/s00467-017-3656-x

Mehmood, H. R., Khan, Z., Jahangir, H. M. S., Hussain, A., Elahi, A., & Askari, S. M. H. (2022). Assessment of serum biochemical derangements and associated risk factors of chronic kidney disease. Journal of Taibah University Medical Sciences, 17(3), 376–383. https://doi.org/10.1016/j.jtumed.2021.09.009

Nelms, C. L., Shaw, V., Greenbaum, L. A., Anderson, C., Desloovere, A., Haffner, D., Oosterveld, M. J. S., Paglialonga, F., Polderman, N., Qizalbash, L., Rees, L., Renken-Terhaerdt, J., Tuokkola, J., Vande Walle, J., Shroff, R., & Warady, B. A. (2021). Assessment of nutritional status in children with kidney diseases—Clinical practice recommendations from the Pediatric Renal Nutrition Taskforce. Pediatric Nephrology, 36(4), 995–1010. https://doi.org/10.1007/s00467-020-04852-5

Tufenkjy, E., & Lahdo, R. (2025). Hemodialysis and minerals in end stage renal disease. Clinica Chimica Acta, 577, 120485. https://doi.org/10.1016/j.cca.2025.120485.

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2026-09-30